Clinical application of combined detection of serum macrophage inhibitory cytokine-1, carcinoembryonic antigen and carbohydrate antigens for the diagnosis and prognosis of colorectal cancer in the elderly
10.3760/cma.j.issn.0254-9026.2019.11.024
- VernacularTitle: 血清巨噬细胞抑制因子-1癌胚抗原及糖类抗原联合检测在老年结直肠癌诊断和预后中的应用
- Author:
Xiaoyong CHEN
1
;
Liya DENG
2
;
Shihai XUAN
3
;
Xin CHEN
1
Author Information
1. Laboratory Department, Dongtai People's Hospital, Jiangsu 224200, China
2. Laboratory Department, Dongtai Third People's Hospital, Jiangsu 224200, China
3. Science and Education Department, Dongtai People's Hospital, Jiangsu 224200, China
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Macrophage migration-inhibitory factors;
Carcinoembryonic antigen;
Antigens, tumor-associated, carbohydrate
- From:
Chinese Journal of Geriatrics
2019;38(11):1289-1293
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of combined detection of serum macrophage inhibitory cytokine-1(MIC-1), carcinoembryonic antigen(CEA)and carbohydrate antigens in the diagnosis and prognosis of elderly patients with colorectal cancer.172 elderly patients with colorectal cancer were selected retrospectively as the observation group, 175 elderly patients with benign colorectal lesions were enrolled as the benign lesion group and 166 healthy elderly subjects as the control group.
Methods:The levels of MIC-1, CEA, carbohydrate antigens of 199(CA199), 724(CA724), 242(CA242), 125(CA125), and 50(CA50)were compared among the three groups, and the diagnostic efficacy was calculated.The difference in the above-mentioned indicators between patients with different stages and prognosis in the observation group were compared.
Results:Levels of MIC-1, CEA, CA199, CA242, CA724, CA125 and CA50 were higher in the observation group than in the benign lesion group and the control group, and the above indexes were higher in the benign lesion group than in the control group.The sensitivity, positive predictive value and negative predictive value of MIC-1 were the highest in single index test(68.6%, 72.8% and 84.6%, respectively). The specificity of CA199 was the highest(91.2%). The combined detections greatly improved sensitivity, positive predictive value and negative predictive value(89.0%, 79.3% and 94.1%, respectively). In the observation group, levels of MIC-1, CEA, CA199, CA242, CA724, CA125 and CA50 in the elderly colorectal cancer patients were higher in stage Ⅲ and Ⅳ than in stage Ⅰ and Ⅱ.The levels of MIC-1, CEA, CA199, CA242, CA724, CA125 and CA50 in elderly patients with recurrence and metastasis of colorectal cancer were higher than those in patients without recurrence and metastasis.
Conclusions:Combined detection of multiple indicators can improve the sensitivity of diagnosis, and is more conducive to the early diagnosis of elderly patients with colorectal cancer.
