Correlation of serum growth differentiation factor-15 level with degree of coronary artery lesion and prognosis in elderly patients with acute coronary syndrome
10.3760/cma.j.issn.0254-9026.2019.11.009
- VernacularTitle: 老年急性冠状动脉综合征患者生长分化因子15与冠状动脉病变程度和预后关系
- Author:
Baoliang GUO
1
;
Zhanlu LI
2
Author Information
1. Department of Cardiology, Hangzhou Xixi Hospital, Hangzhou 310023, China
2. Department of Cardiology, Shaoyifu Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310020, China
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Growth differentiation factors;
Prognosis
- From:
Chinese Journal of Geriatrics
2019;38(11):1229-1231
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of growth differentiation factor-15(GDF-15)level with the severity of coronary artery disease and prognosis and in elderly patients with acute coronary syndrome.
Methods:A total of 168 elderly patients with acute coronary syndrome admitted into Hangzhou Xixi Hospital and Shaoyifu Hospital Affiliated to Medical College of Zhejiang University from March 2017 to April 2018 were enrolled in the study.Patients were divided into three groups: GDF-15>1 800 μmol/L(n=28), GDF-15 between 1 200-1 800 μmol/L(n=45), and GDF-15<1 200 μmol/L(n=95). Plasma levels of high-sensitivity C-reactive protein(hs-CRP)and GDF-15, and SYNTAX score, single-vessel-, double-vessel, multi-vessel coronary disease and major adverse cardiovascular events(MACE)were analyzed and compared between groups.
Results:Plasma levels of hs-CRP and GDF-15 had significant differences among the three groups(P<0.05). There were significant statistically differences in SYNTAX score, single-vessel, double-vessel and multi-vessel coronary disease and MACE among the three groups(P<0.05). Logistic regression analysis showed that the levels of GDF-15(OR=2.092, 95%CI: 1.585~2.687), SYNTAX score(OR=1.948, 95%CI: 1.097~2.098), double-vessel lesions(OR=1.124, 95%CI: 1.006~1.251)and multi-vessel lesions(OR=1.744, 95%CI: 1.149~2.642)(all P<0.05)were statistically significant influencing factors for the prognosis.
Conclusions:GDF-15 level is correlated with SYNTAX score, double-vessel lesions and multi-vessel lesions, and could predict the severity of coronary artery lesions and prognosis in patients with acute coronary syndrome.
