Advances of Nogo-A protein in the mechanism of epilepsy

VernacularTitle: Nogo-A蛋白参与癫痫发生机制的研究进展
Author: Jinwei ZHANG ^{1
,

2} ; Tao CHEN ^{1
,

2} ; Sixun YU ¹ ; Haifeng SHU ¹ ; Yongqin KUANG ^{1
,

2}
Author Information

1. Department of Clinical Medicine, Chengdu Medical College, Chengdu 610500, China
2. Department of Neurosurgery, the General Hospital of Western Theater Command of People′s Liberation Army, Chengdu 610083, China
Publication Type:Review
Keywords: Nogo-A; Epilepsy; Dendrites; Glia; Nerve migration
From: Chinese Journal of Neurology 2019;52(11):967-973
CountryChina
Language:Chinese
Abstract: The myelin-associated protein Nogo-A was considered to be the axon growth inhibitory factor, which participates in a variety of pathophysiological regulation of nervous system. In recent years, a growing number of studies have shown that Nogo-A protein is closely related to epilepsy by regulating dendritic plasticity, mediating abnormal nerve migration and regulating glial cell activation, etc. This article will review the research progress of Nogo-A in epilepsy in recent years.