Peripheral nerve hyperexcitability syndromes
10.3760/cma.j.issn.1006-7876.2019.11.017
- VernacularTitle: 周围神经过度兴奋综合征
- Author:
Zhili WANG
1
;
Jingwen NIU
1
;
Liying CUI
1
,
2
Author Information
1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
2. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730, China
- Publication Type:Review
- Keywords:
Myokymia;
Neuromyotonia;
Peripheral nerve hyperexcitability;
Isaacs syndrome;
Morvan syndrome
- From:
Chinese Journal of Neurology
2019;52(11):957-961
- CountryChina
- Language:Chinese
-
Abstract:
Peripheral nerve hyperexcitability syndromes (PNHS) encompass a spectrum of a heterogeneous condition with clinical as well as electrophysiological manifestations of peripheral nerve hyperexcitability. The PNHS consist of Isaacs syndrome, Morvan syndrome and Cramp-fasciculation syndrome, which cause widespread symptoms and signs while without evident peripheral nerve disease. Probably the most well-known condition of PNHS is Isaacs syndrome, often called acquired neuromyotonia. Clinical symptoms of PNHS are characterized by muscle twitching, cramps, stiffness, and neuropathic pain. The electrophysiological findings that are very useful in the diagnosis of PNHS are spontaneous myokymic, neuromyotonic, and cramp discharges. An overview of the history, clinical manifestations, pathophysiology, electrophysiological findings and management of PNHS is presented.
