A case report of B2 thymoma with anti-α-amino-3-hydroxy-5-methyl-4-isoxazolipropionic acid receptor antibody encephalitis
10.3760/cma.j.issn.1006-7876.2019.11.014
- VernacularTitle: B2型胸腺瘤合并抗α-氨基-3-羟基-5-甲基-4-异唑丙酸受体抗体脑炎一例
- Author:
Jian WANG
1
;
Zucai XU
2
Author Information
1. Department of Neurology, Guizhou Aerospace Hospital, Zunyi, Guizhou 563003, China
2. Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China
- Publication Type:Case Reports
- Keywords:
Encephalitis;
Autoimmunity;
Anti-α
-amino-3-hydroxy-5-methyl-4-isoxazolipropionic acid receptor;
Thymoma
- From:
Chinese Journal of Neurology
2019;52(11):945-947
- CountryChina
- Language:Chinese
-
Abstract:
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolipropionic acid receptor (AMPAR) encephalitis is an autoimmune encephalitis that is resistant to neuron cell surface antigen, and the clinical incidence is rare. We report a new case of AMPAR encephalitis with clinical features and management. A male patient, 56 years old, presented with progressive dizziness with difficulty swallowing disorder in acute onset. Chest CT examination revealed thymoma and thymic tumor resection was done. Postoperative dizziness and swallowing difficulties were still in progression, with abnormal mental behavior, disturbance of consciousness, seizures, etc. Cerebral MRI showed multiple long T1 and long T2 signals, as well as high fluid attenuated inversion recovery signal lesions in bilateral parietal lobe, bilateral frontal lobe, left occipital lobe, bilateral temporal lobe and right hippocampus. Serum glutamate receptor (AMPA2) antibody IgG was found positive. Based on the patient′s clinical manifestations, auxiliary examination and literature review, the patient was diagnosed as AMPAR encephalitis and received immunotherapy. After active treatment, the patient′s symptoms improved and he then discharged from hospital. Serum or cerebrospinal fluid antibody detection is helpful for early diagnosis and treatment of the disease.
