Evaluating the impact of psoriasis on cognitive function in mouse models by using Morris water maze

Lei HE; Jun Chen; Lili Chen; Xuefei LI; Hao Wang; Lijun Liu; Shucun Qin; Baoqiang LI; Xinsuo Duan

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Evaluating the impact of psoriasis on cognitive function in mouse models by using Morris water maze

VernacularTitle: 应用Morris水迷宫实验评估银屑病对小鼠模型认知功能的影响
Author: Lei HE ¹ ; Jun CHEN ¹ ; Lili CHEN ¹ ; Xuefei LI ¹ ; Hao WANG ² ; Lijun LIU ¹ ; Shucun QIN ² ; Baoqiang LI ¹ ; Xinsuo DUAN ¹
Author Information

1. Department of Dermatology and Venereology, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China
2. Institute of Atherosclerosis, Shandong First Medical University, Taian 271000, Shandong, China
Publication Type:Case Reports
Keywords: Psoriasis; Cognition disorders; Learning disorders; Memory disorders; Disease models, animal; Morris water maze
From: Chinese Journal of Dermatology 2019;52(11):836-839
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the impact of psoriasis on spatial learning and memory abilities in mouse models by using Morris water maze.
Methods:Twenty healthy male C57BL/6J mice aged 10 months were randomly and equally divided into 2 groups: psoriasis group topically treated with imiquimod 5% cream on the back once a day for a week, and control group topically treated with vaseline once a day for a week. After successful establishment of mouse models, the Morris water maze (MWM) test was used to assess the learning and memory abilities in the mice in the 2 groups.
Results:In the place navigation experiment, the escape latency was significantly longer in the psoriasis group (38.24 ± 13.59 s) than in the control group (14.28 ± 3.80 s, t = 5.37, P < 0.01) . In the spatial probe test, the number of times passing through the platform (1.70 ± 0.95 vs. 5.00 ± 1.76, t = 5.21, P < 0.01) , the duration of stay in the target quadrant (t = 2.80, P < 0.05) and the swimming distance (t = 5.74, P < 0.01) were all significantly lower in the psoriasis group than in the control group. The psoriasis group showed significantly decreased swimming distance in the second quadrant (t = 2.49, P < 0.05) , but significantly longer duration of stay in the fourth quadrant compared with the control group (t = 2.46, P < 0.05) . There were no significant differences in swimming distance or duration of stay in other quadrants between the psoriasis group and control group (all P > 0.05) .
Conclusion:The spatial learning and memory abilities were impaired in the mouse model of psoriasis.