Advances in the research of effects and regulatory mechanism of regulatory T cells in tissue injury and repair
10.3760/cma.j.issn.1009-2587.2019.11.013
- VernacularTitle: 调节性T细胞在组织损伤修复中的作用及其调控机制研究进展
- Author:
Kunwei CHEN
1
;
Yalin TONG
2
;
Yongming YAO
1
Author Information
1. Trauma Research Center, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China
2. Department of Burns and Plastic Surgery, the 181st Hospital of PLA, Guilin 541002, China
- Publication Type:Review
- Keywords:
Regenerative medicine;
Adaptive immunity;
Regulatory T cells;
Tissue injury and repair
- From:
Chinese Journal of Burns
2019;35(11):828-832
- CountryChina
- Language:Chinese
-
Abstract:
The repair strategy after organs injuries has always been a hot topic in the field of regenerative medicine. Traditional injury repair measures mainly promote tissue repair through mesenchymal stem cells and various growth factors, but these strategies have been constrained in the aspects of security and economy. Hence, there is an urgent need to find new ways to promote tissue repair and regeneration. There have been a lot of evidences showing that the immune system plays an important role in tissue regeneration and repair. In recent years, more and more studies have been done on adaptive immunity in tissue repair, especially the regulatory T cells. Some evidences indicate that regulatory T cells participate in damage tissue repair and regeneration of multiple organs and tissue. This review briefly introduces the new advances in the repair effects and regulatory mechanism of regulatory T cells in different organ injuries, in order to provide new ideas for designing advanced repair materials with good immunoregulatory functions.
