Sero-epidemiological characteristics of hepatitis E in population aged 1-29 years in China, 2014
10.3760/cma.j.issn.0254-6450.2019.11.016
- VernacularTitle: 我国2014年1~29岁人群戊型肝炎血清流行病学特征分析
- Author:
Fuzhen WANG
1
;
Xiaojin SUN
1
;
Feng WANG
2
;
Jianhua LIU
3
;
Guomin ZHANG
1
;
Hui ZHENG
1
;
Ning MIAO
1
;
Shuang ZHANG
2
;
Wei ZHANG
1
;
Shengli BI
2
;
Fuqiang CUI
4
;
Liping SHEN
2
;
Xiaofeng LIANG
5
Author Information
1. Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
2. Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
3. Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China
4. School of Public School, Peking University Health Science Center, Beijing, 100191, China
5. Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
Hepatitis E;
Serology;
Epidemiologic characteristic
- From:
Chinese Journal of Epidemiology
2019;40(11):1426-1431
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the epidemiological characteristics of hepatitis E Virus antibody (anti-HEV) in people aged 1-29 years in China in 2014.
Methods:Based on database of the national serologic survey of hepatitis B in people aged 1-29 years in China, in 2014, the sample size was estimated. The serum samples of the people surveyed were randomly selected to detect anti-HEV IgG by using enzyme- linked immunosorbent assay (ELISA). Statistical software SAS 9.1.3 was used to calculate the positive rate of anti-HEV and 95% confidence interval (CI) in different age, gender groups, urban and rural areas and geographic areas by using the Taylor series linear method with sampling weight. The difference was determined by comparing 95%CI.
Results:A total of 14 106 serum samples were detected from people aged 1-29 years, including 6 996 males (49.60%), 7 013 urban residents (49.72%). The positive rate of anti-HEV was 8.12%(95%CI: 7.19-9.15) in people aged 1-29 years. There was no statistical difference between the men and women, between urban area and rural area. The positive rates of anti-HEV in western area(11.36%, 95%CI: 9.45-13.62) was higher than those in eastern and central areas. The positive rates of anti-HEV were 2.46%, 2.24%, 4.50%, 7.58%, 11.89% and 17.27% in people aged 1-, 5-, 10-, 15-, 20- and 25-29 years, respectively. As the age increased, the positive rate of anti-HEV gradually increased. In different ethnic groups, the positive rate of anti-HEV was higher in Tibetan (18.32%, 95%CI: 12.02-26.90), Zhuang (9.54%, 95%CI: 4.33-19.73) ethnic groups.
Conclusion:The positive rate of anti-HEV declined slightly in China in 2014. It is still necessary to pay close attention to the HEV infection, morbidity of hepatitis E and risk factors in people aged 1-29 years.
