Environment-responsive fluorescence probes in image-guided surgery
10.3760/cma.j.issn.2095-2848.2019.11.014
- VernacularTitle: 环境响应型荧光探针在手术导航中的应用
- Author:
Jing ZHU
1
;
Chengchao CHU
;
Gang LIU
Author Information
1. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
- Publication Type:Review
- Keywords:
Molecular probes;
Fluorescence;
Tumor microenvironment;
Enzymes;
Hydrogen-ion concentration;
Cell hypoxia;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(11):694-697
- CountryChina
- Language:Chinese
-
Abstract:
Unlike conventional imaging technologies, fluorescent imaging benefits from its safety, high-spatial resolution and real-time capability, which make it a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. There are two types of fluorescent probes, including always-on type and environment-responsive type, wherein environment-responsive probes are preferred due to higher target-to-background ratios, which can improve sensitivity and specificity. The environment-responsive probes include enzyme-reactive probes, pH-sensitive probes and hypoxia responsive probes. This review summarizes recent progress in environment-responsive probes, and discusses their potentials in tumor detection and image-guided surgery.
