Clinical features and prognosis of extrahepatic biliary neuroendocrine neoplasms
10.3670.cma.j.issn.1007-631X.2019.11.015
- VernacularTitle: 胆道系统神经内分泌肿瘤的病理和预后
- Author:
Guowu QIAN
1
;
Jingjing HUANG
2
;
Xinxin DUAN
3
;
Wanri SUN
1
;
Chi LIU
1
;
Zhan SONG
1
Author Information
1. Department of General Surgery, the Affiliated Nanyang Central Hospital, Zhengzhou University, Nanyang 473009, China
2. Department of General Surgery, the First Hospital Affiliated to Henan University of Chinese Medicine, Zhengzhou 450000, China
3. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Neuroendocrine tumors;
Common bile duct neoplasms;
Survival analysis
- From:
Chinese Journal of General Surgery
2019;34(11):964-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and prognostic factors of extrahepatic biliary neuroendocrine neoplasms(EB-NENs).
Methods:The clinical data and survival of 21 patients with EB-NENs admitted from May 2014 to May 2018 were analyzed retrospectively.
Results:These 21 EB-NENs patients accounted for 1.6% (21/1313) of all biliary tract neoplasms treated during the study period. Seven (33.3%) cases had lymph node metastasis. Five (23.8%) suffered from distant metastasis. The follow up time was (4~46.5) months with median survival time of (23.23 ±4.17) months. Univariate analysis showed that the risk factors for survival were tumor TNM stage (χ2=9.066, P=0.003), lymph node metastasis(χ2=6.399, P=0.011) and distant metastasis (χ2=9.808, P=0.002). By multivariate analysis, independent risk factors were tumor TNM stage(P=0.008, RR=3.003, 95% CI: 1.332~6.774), lymph node metastasis(P=0.023, RR=5.382, 95% CI: 1.261~22.971) and distant metastasis or not(P=0.007, RR=7.423, 95% CI: 1.730~31.851).
Conclusion:EB-NENs was a rare malignant tumor with poor prognosis. Tumor TNM stage, lymph node metastasis and distant metastasis were independent prognostic factors for EB-NENs patients.
