Radiation-induced changes in small world network in patients with nasopharyngeal carcinoma: a three-dimensional structure MRI imaging study
10.3760/cma.j.issn.1004-4221.2019.11.003
- VernacularTitle: 鼻咽癌患者放疗引发小世界网络变化：三维结构MRI数据研究
- Author:
Xin XIN
1
;
Chuandong CHENG
1
;
Churong LI
1
;
Jie LI
1
;
Pei WANG
1
;
Yin TIAN
2
;
Gang YIN
1
;
Jinyi LANG
1
Author Information
1. Department of Radiation Oncology, Sichuan Cancer Hospital/Radiation Oncology Key Laboratory of Sichuan Province, Chengdu 610041, China
2. Chongqing University of Posts and Telecommunications, Chongqing 404100, China
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasm/radiotherapy;
Voxel-based morphometry;
Gray matter;
Small world property
- From:
Chinese Journal of Radiation Oncology
2019;28(11):811-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the radiotherapy (RT)-induced changes in the brain structural network in patients with nasopharyngeal carcinoma (NPC).
Methods:Three-dimensional structural magnetic resonance data (3D-T1W) was adopted to investigate the structural network in 103 patients with NPC before and after receiving RT. The structural networks were then reconstructed using 3D-T1W. The radiation-induced changes in topology properties of small world network were analyzed by using graph theoretical analysis.
Results:Patients showed small world properties before and after RT. Compared with the pre-RT group, the global and local efficiency were lower, the shortest path length was longer and the clustering coefficient was less in the post-RT group. In addition, the hub regions in the post-RT group were significantly different from those in the pre-RT group, mainly located in the left rolandic operculum, right inferior frontal gyrus, right parahippocampal gyrus, right lingual gyrus, bilateral supramarginal gyrus, left superior temporal gyrus and temporal pole of the right middle temporal gyrus.
Conclusion:It is speculated that RT leads to high efficiency of network topology and information transmission, which provides a novel perspective for exploring the RT-induced brain changes, diagnosis of RT-induced injury and evaluation of RT efficacy.
