Advances in the detection and clearance of hepatitis B virus covalently closed circular DNA (cccDNA)
10.3760/cma.j.issn.0254-5101.2019.11.011
- VernacularTitle: 乙型肝炎病毒共价闭合环状DNA(cccDNA)检测和清除的研究进展
- Author:
Yuan TIAN
1
;
Feng REN
Author Information
1. Beijing Institute of Hepatology, Beijing You′an Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Review
- Keywords:
HBV;
cccDNA;
Detection;
Elimination
- From:Chinese Journal of Microbiology and Immunology
2019;39(11):875-879
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B (CHB) is a worldwide public health problem and current therapeutic drugs cannot completely eliminate the covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) in the liver cell nucleus. The presence of cccDNA leads to the persistent HBV infection, which is hard to be completely eliminated. At present, the research on cccDNA is getting increasing attention. Only by comprehensively understanding it can we find a better way to cure HBV infection. This article reviewed the structure, regulation, detection and elimination of HBV cccDNA.
