Effect of maternal malignant tumor on the neonatal outcome
10.3760/cma.j.issn.2095-428X.2019.11.003
- VernacularTitle: 母亲患恶性肿瘤性疾病对新生儿的影响
- Author:
Jing DING
1
;
Jie LIU
;
Chaomei ZENG
Author Information
1. Department of Pediatrics, Peking University People′s Hospital, Beijing 100044, China
- Publication Type:Journal Article
- Keywords:
Maternal cancer;
Pregnancy;
Chemotherapy;
Infant, newborn
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(11):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of maternal malignant tumor and related therapy on the outcome of newborns.
Methods:The clinical data of 78 pregnant women with malignant tumors and 15 newborns whose mothers suffered from malignant tumors between January 2011 and December 2016 in Peking University People′s Hospital were studied.At the same time, 64 cases of pregnant women with no disease were randomly selected as the control group, and the effect of maternal malignant tumors and related therapy on neonatal growth and development were analyzed.
Results:Among the 78 pregnant women suffering from malignant tumors, 14 women chose abortion or induced labor, and 64 women chose to continue pregnancy until delivery.Among the 78 women, 23 cases suffered from acute leukemia, 20 cases suffered from chronic myeloid leukemia, 11 cases suffered from cervical cancer, 9 cases suffered from thyroid carcinoma, 6 cases suffered from unclassified leukemia, 3 cases suffered from oophoroma, 3 cases suffered from lymphoma, 2 cases suffered from endometrial carcinoma and 1 case suffered from invasive mole.Among the 64 mothers, 20 mothers did not receive any treatment during pregnancy and 44 cases received chemotherapy or other treatments such as intermittent transfusion therapy.Among the 64 newborns, 24 cases were vaginal deliveries, 6 cases were forceps deli-very and 34 cases were caesarean section.The mean gestational age [(37.6±2.3) weeks vs.(40.0±1.2) weeks], body weight[(2 998±637) g vs.(3 389±360) g]and body length[(48.5±2.8) cm vs.(50.2±1.5) cm]at birth of neonates, whose mothers with malignant tumors during pregnancy were smaller than those of the control group, and the differences were statistically significant (all P<0.05). The incidence of small for gestational age[7.8%(5/64 cases) vs.0(0/64 cases)], late preterm infants[25.0%(16/64 cases) vs.1.6%(1/64 cases)], low birth weight infants[20.3%(13/64 cases) vs.0(0/64 cases)], caesarean section rate[53.1%(34/64 cases) vs.31.2%(20/64 cases)] and the neonatal intensive care unit(NICU) admission[23.4%(15/64 cases) vs.1.6%(1/64 cases)] were higher than those of the control group, but the incidence of term infants was lower [70.3%(45/64 cases) vs.98.4%(63/64 cases)], and the differences were statistically significant (all P<0.05). Among the 15 neonates, there was only one neonate who was admitted to hospital 4 days after birth, while the other 14 newborns were all admitted within 2 hours after birth.Their average hospitalization time was (8.9±4.3)days.Among the 15 neonates, 1 case had congenital heart malformation and 6 cases suffered from infection.The average number of white blood cells, hemoglobin and platelet were (14.7±4.3)×109/L, (170.6±21.4) g/L and (220±63.7)×109/L, respectively.The first biochemical tests of the 15 newborns showed that 1 case had elevated alanine aminotransferase, 3 cases had elevated glutamic-oxalacetic transaminase, 1 case suffered from hypoglycemia and another one suffered from hyperglycemia.While albumin, cholesterol, triglyceride, urea nitrogen and creatinine were all in the normal range.
Conclusions:Maternal cancer and related therapy increase the incidence of premature, cesarean section and NICU admission of their offspring.Meanwhile, it can also affect the growth, hematologic system and liver function of some newborns.
