Gastric Adenocarcinoma Secondary to Primary Gastric Diffuse Large B-cell Lymphoma.
- Author:
Riwa SAKR
1
;
Marcel MASSOUD
;
Georges AFTIMOS
;
Georges CHAHINE
Author Information
- Publication Type:Case Report
- Keywords: Neoplasms, second primary; Stomach neoplasms; Lymphoma
- MeSH: Adenocarcinoma*; Aged; B-Lymphocytes*; Doxorubicin; Drug Therapy; Gastritis; Helicobacter pylori; Humans; Incidence; Lymphoma; Lymphoma, B-Cell*; Mortality; Neoplasms, Second Primary; Prednisolone; Risk Factors; Stomach Neoplasms; Vincristine
- From:Journal of Gastric Cancer 2017;17(2):180-185
- CountryRepublic of Korea
- Language:English
- Abstract: Despite the decreasing incidence and mortality from gastric cancer, it remains a major health problem worldwide. Ninety percent of cases are adenocarcinomas. Here, we report a case of gastric adenocarcinoma developed after successful treatment of prior primary gastric diffuse large B-cell lymphoma (DLBCL). Our patient was an elderly man with primary gastric DLBCL in whom complete remission was achieved after R-CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone plus rituximab) chemotherapy. Helicobacter pylori infection persisted despite adequate treatment leading to sustained chronic gastritis. The mean time to diagnose metachronous gastric carcinoma was seven years. We believe that a combination of many risk factors, of which chronic H. pylori infection the most important, led to the development of gastric carcinoma following primary gastric lymphoma. In summary, patients who have been successfully treated for primary gastric lymphoma should be followed up at regular short intervals. H. pylori infection should be diagnosed promptly and treated aggressively.
