Progress in role of iron in pathogenesis of preeclampsia
10.3760/cma.j.issn.1007-9408.2019.11.010
- VernacularTitle: 铁与子痫前期发病的研究进展
- Author:
Jie DONG
1
;
Jianying YAN
2
;
Qinjian ZHANG
2
Author Information
1. Graduate School of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China
2. Department of Obstetrics and Gynecology, Fujian Maternal and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China
- Publication Type:Review
- Keywords:
Pre-eclampsia;
Iron;
Oxidative stress
- From:
Chinese Journal of Perinatal Medicine
2019;22(11):812-816
- CountryChina
- Language:Chinese
-
Abstract:
Iron plays an important role in maintaining normal physiological functions of oxygen transportation and electron transfer in the body. However, excessive iron intake will induce the generation of oxygen radicals through Fenton reaction and result in free radical chain reactions, causing lipid peroxidation and DNA damage. Oxidative stress is also known as one of the causes of preeclampsia. Therefore, the correlation between iron overload and preeclampsia has attracted more attention. Relevant publications were reviewed to discuss the potential mechanisms of iron overload under oxidative stress in the pathogenesis of preeclampsia.
