In vitro study of histocompatibility and clearance of hemoperfusion adsorbents
10.3760/cma.j.issn.1001-9391.2019.011.013
- VernacularTitle: 血液灌流吸附材料组织相容性和有效性的体外实验
- Author:
Xiang GUO
1
;
Peimao LI
;
Yanfang ZHANG
;
Jian HE
;
Hui LIN
;
Meiqiong GUO
Author Information
1. Shenzhen Prevention and Treatment Center for Occupational Disease, Shenzhen 518020, China
- Publication Type:Journal Article
- Keywords:
Hemoperfusion;
Adsorbents;
Chlorpyrifos;
In vitro test
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(11):848-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the histocompatibility and clearance of chlorpyrifos and its metabolite of activated charcoal and adsorption resin by in vitro study.
Methods:Venous blood from volunteers were incubation with activated charcoal or adsorbent resins, cytometry parameters and plasma components were detected for evaluation the histocompatibility of adsorbents. Venous blood from volunteers mixed with chlorpyrifos and its metabolite were incubation with activated charcoal or adsorbent resins, plasma concentration of chlorpyrifos and its metabolite were detected for evaluation the efficacy of adsorbents.
Results:Incubation tests show that the absorbents reduce the blood platelet (F=3.671, P<0.05) , serum glucose (F=10.564, P<0.05) , albumin (F=5.239, P<0.05) , uric acid (F=7.175, P<0.05) , creatinine (F=23.673, P<0.05) , T3 (F=11.161, P<0.05) and free T3 (F=10.256, P<0.05) . However, other cytometry parameters and plasma components were not influenced. Both activated charcoal and adsorbent resins could reduce the plasma concentration of chlorpyrifos (F=798.110, P<0.01) and its metabolite (F=1495.212, P<0.05) .
Conclusion:In vitro test show that both activated charcoal and adsorbent resins could clear chlorpyrifos and its metabolite, however, could not influence main cytometry parameters and plasma components, the histocompatibility of adsorbents are satisfactory.
