High serum cholesterol: a novel risk factor for thyroid associated ophthalmopathy?
10.3760/cma.j.issn.0578-1426.2019.11.007
- VernacularTitle: 高胆固醇血症：甲状腺相关性眼病新的发病危险因素？
- Author:
Xiaozhen YE
1
;
Shanshan HUANG
;
Jun LIU
;
Bin LU
;
Jiaqing SHAO
Author Information
1. Department of Endocrinology, Jinling Hospital, Nanjing 210002, China
- Publication Type:Case Reports
- Keywords:
Thyroid associated ophthalmopathy;
Hypercholesterolemia
- From:
Chinese Journal of Internal Medicine
2019;58(11):823-825
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the association between dyslipidemia and thyroid associated ophthalmopathy (TAO). We evaluated the relationship between dyslipidemia and TAO in 218 patients with Graves′ disease (GD) and found that the serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the GD subjects with TAO (n=110) were significantly increased [(5.32±1.39) mmol/L vs. (3.18±2.12) mmol/L, (2.98±0.75) mmol/L vs. (1.25±0.98) mmol/L] than those in the GD subjects without TAO (n=108). TC and LDL-C were positively correlated with the Clinical disease activity score (CAS) [TC (r=0.7, P=0.03),LDL-C (r=0.82, P=0.03)], and the levels of TC (OR=2.56, P=0.02) and LDL-C(OR=2.01, P=0.015) were positively associated with TAO. These suggested that high serum cholesterol level is a novel risk factor for TAO, and management of blood lipids should be included in the treatment of TAO.
