The efficacy and safety of co-transplantation of unrelated donor peripheral blood stem cells combined with umbilical mesenchymal stem cells in patients with refractory severe aplastic anemia-Ⅱ

VernacularTitle: 无关供者外周血干细胞联合脐血间充质干细胞共移植治疗难治性重型再生障碍性贫血Ⅱ型的疗效及安全性
Author: Mingyue ZHAO ¹ ; Yuewen FU ; Qian WANG ; Hao AI ; Yongqi WANG ; Tingting LI ; Jian ZHOU ; Baijun FANG ; Xudong WEI ; Yongping SONG
Author Information

1. Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450000, China
Publication Type:Case Reports
Keywords: Unrelated donor peripheral blood stem cells; Umbilical cord mesenchymal stem cells; Refractory severe aplastic anemia
From: Chinese Journal of Internal Medicine 2019;58(11):819-822
CountryChina
Language:Chinese
Abstract: The efficacy and safety of co-transplantation of unrelated donor peripheral blood stem cells (UD-PBSCs) combined with umbilical cord mesenchymal stem cells (UC-MSCs) in refractory severe aplastic anemia-Ⅱ(RSAA-Ⅱ) were analyzed retrospectively. Fifteen patients with RSAA-Ⅱ underwent UD-PBSCs and UC-MSCs co-transplantation, among whom 14 cases had hematopoietic reconstitution without severe graft versus-host disease (GVHD). The 5-year overall survival rate was 78.57%. Combination of UD-PBSCs and UC-MSCs transplantation could be a safe and effective option for RSAA-Ⅱ.