Research progress on the mutual effects between brown adipose tissue and bone
10.3760/cma.j.issn.1000-6699.2019.11.014
- VernacularTitle: 棕色脂肪组织与骨相互关系的研究进展
- Author:
Mengyue SUN
1
;
Qi YUAN
;
Jinglei YANG
;
Ridong ZHANG
;
Shan TANG
;
Sha TAO
;
Li MAO
Author Information
1. Department of Endocrinology, The Affiliated Huaian No.1 People′s Hospital of Nanjing Medical University, Huaian 223300, China
- Publication Type:Journal Article
- Keywords:
Brown adipose tissue;
Bone metabolism;
Endocrine factors
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(11):995-998
- CountryChina
- Language:Chinese
-
Abstract:
Brown adipose tissue (BAT) increases energy consumption by directly dissipating stored energy in the form of heat through the role of uncoupling protein (UCP1). Recent studies have found that brown adipocytes may also regulate metabolism through autocrine, paracrine, and endocrine mechanisms. A growing body of evidences have shown that the BAT has a close relationship with bone metabolism, in which BAT secretes a variety of factors to regulate bone metabolism, while bone also secretes a variety of bioactive substances to control BAT function. In addition, BAT may indirectly participate in bone metabolism through muscle-mediated regulation or SNS activity and improvement of body metabolism, thus forming a BAT-skeletal axis. In this paper, we try to explain the relationship between brown adipose tissue and bone, and to discuss their interactive mechanisms.
