Screening and analysis of the serum thyroid stimulating hormone (TSH) of rural pregestational women In Yunnan province
10.3760/cma.j.issn.1000-6699.2019.11.008
- VernacularTitle: 云南省农村地区育龄妇女孕前血清促甲状腺激素筛查及分析
- Author:
Zhengyuan XIE
1
;
Genrui LI
1
;
Juanjuan CHEN
1
;
Hong SUN
1
;
Guang CAO
2
Author Information
1. Key Laboratory for Fertility Regulation and Minority Birth Health Research of Yunnan Province, Key Laboratory of Preconception Health in Western China, NHFPC, Population and Family Planning Institute of Yunnan Province, Kunming 650021, China
2. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
- Publication Type:Clinical Trail
- Keywords:
Thyroid stimulating hormone;
Pregestational Women;
Rural areas;
Minority of Yunnan Province
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(11):962-968
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Through screening the serum TSH in rural pregestational women, fo find out the high incidence area and high risk population of thyroid disease in Yunnan province, to reduce the probability of infertility and abnormal pregnancy and provide important reference basis for prenatal aristogenesis.
Methods:The serum TSH level of 30 163 rural pregestational women(20-49 yeas old) which from 16 different areas and 16 different ethnicities of Yunnan province was detected by using TSH3-Ultra (TSH3-UL) reagent on a Siemens centar-XP automatic chemiluminescence apparatus.
Results:1 797 women were found with abnormal serum TSH level, the abnormal rate was 5.96%. Among them, the proportion of women with decreased TSH was 3.09% and increased TSH was 2.87%, compared with the normal reference range. And there was a significant difference of abnormal serum TSH rate between pregestational women from different areas and ethnicities. Moreover, in the 16 tested areas, the highest abnormal serum TSH rate was 8.90% from Ximeng county, the lowest was 3.60% from Diqing state. However in the 16 tested ethnicities, the highest abnormal serum TSH rate was 9.73% from Lisu ethnic minority and the lowest was 3.60% from Tibetan ethnic minority.
Conclusions:The results inferred that ethnic and regional factors both to some extent affect the prevalence of thyroid disease in pregestational women and it is a small probability event that high occurrence of TSH decreased or increased situation simultaneously happened in one area or one ethnicity.
