Relationship between sex hormones, lipids and visceral fat area in postmenopausal women with type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2019.11.006
- VernacularTitle: 绝经后2型糖尿病患者性激素水平和血脂及内脏脂肪面积的关系
- Author:
Ran ZHAO
1
;
Hui HAN
2
;
Chunxiao YU
1
;
Qingbo GUAN
1
Author Information
1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
2. Lung Function Room of Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
- Publication Type:Clinical Trail
- Keywords:
Diabetes mellitus, type 2;
Postmenopausal women;
Sex hormones;
Blood lipids;
Visceral fat area
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(11):950-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the characteristics and correlation of sex hormone levels, blood lipids, and visceral fat area in postmenopausal women with T2DM.
Methods:A total of 258 cases of postmenopausal T2DM were recruited, including 46 cases of menopause for 1-5 years (group A), 49 cases of menopause for 6-10 years (group B), and 163 cases with menopause more than 10 years (C group). The related clinical information of patients was recorded.
Results:Compared among the three groups, there were statistical differences in total cholesterol(F=3.287, P=0.039) and testosterone(Chi-Square=8.324, P=0.016). No significant difference in FSH, LH, estradiol, low density lipoprotein, triglyceride, visceral fat area and subcutaneous fat area(P>0.05) among three groups was observed. After correction of confounding factors, FSH was independently positively related with for total cholesterol and low-density lipoprotein respectively (P=0.006, P=0.009). LH was independently positively related with total cholesterol(P=0.003) and low-density lipoprotein respectively(P=0.003). Estradiol was independently negatively related with total cholesterol(P=0.014) and low-density lipoprotein(P=0.020), respectively. Testosterone was correlated independently with visceral fat area(P=0.008); FSH, LH, estradiol, and testosterone were not correlated to triglyceride and subcutaneous fat area(P>0.05).
Conclusion:(1)In T2DM patients with the increase of postmenopausal time, the total cholesterol increases first, and then decreases; testosterone decreases first, and then increases. (2)In T2DM patients, the total cholesterol and low-density lipoprotein increase with the increase of FSH and LH, increase with the decrease of estradiol, and the area of visceral fat increases with the testosterone together.
