Association between glucagon-like peptide-1 receptor gene polymorphisms and metabolic markers in type 2 diabetic patients
10.3760/cma.j.issn.1000-6699.2019.11.005
- VernacularTitle: 胰升糖素样肽1受体基因多态性与2型糖尿病代谢指标的相关性研究
- Author:
Rui LI
1
;
Ying YIN
2
;
Yuedong XU
3
;
Kunrong WU
1
;
Xiaoli LI
2
;
Yan LI
1
Author Information
1. Department of Pharmacy, Qianfoshan Provincial Hospital, Jinan 250014, China
2. School of Pharmacy, Shandong First Medical University, Taian 271000, China
3. Department of Endocrinology, Qianfoshan Provincial Hospital, Jinan 250014, China
- Publication Type:Clinical Trail
- Keywords:
Glucagon-like peptide-1 receptor gene;
Gene polymorphism;
Type 2 diabetes;
Serum lipids;
Blood glucose
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(11):945-949
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution of polymorphisms of glucagon-like peptide-1 receptor gene (GLP-1R) rs10305420 and rs3765467 in Chinese Han type 2 diabetic patients, and the effects on body weight, blood glucose and serum lipid levels.
Methods:Two SNPs of GLP-1R rs3765467 and rs10305420 were genotyped by Sanger dideoxy termination sequencing method. The racial difference and the association between the gene polymorphisms and the metabolic markers including BMI, serum lipids and blood glucose were analyzed.
Results:The distribution of gene polymorphisms was consistent with the Hardy-Weinberg equilibrium. High-density lipoprotein (HDL-C) levels were significantly lower in the rs10305420 T allele carriers than in the CC genotype (1.00±0.18 vs 1.09±0.22, P=0.02). The triglyceride (TG) level of the rs3765467 A allele carrier was higher than that of the GG type (2.75±2.19 vs 2.07±1.36, P=0.03). The allele frequency of rs10305420 C/T was highly statistically significant compared with European population (P=0.000 3). The allele frequency of rs3765467 G/A was statistically different from that of European and African populations (P<0.01).
Conclusions:The two genetic polymorphisms were significantly associated with lipid levels in patients with type 2 diabetes, and there was a significant racial difference in the frequency distribution of the two variants.
