Effect of combination therapy with sitagliptin on abdominal visceral fat area in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1671-7368.2019.11.013
- VernacularTitle: 联用西格列汀治疗2型糖尿病患者腹腔内脏脂肪面积的变化
- Author:
Yun RUAN
1
;
Jiaqi YAO
;
Xiujing WANG
;
Qingying TAN
;
Tianxiao HU
;
Jing WANG
;
Huiling WANG
;
Yao XU
;
Huiling SHEN
Author Information
1. Department of Endocrinology, PLA 903 Hospital, Hangzhou 310013, China
- Publication Type:Journal Article
- Keywords:
Dipeptidyl-peptidase Ⅳ inhibitors;
Diabetes msllitus,type 2;
Intra-abdominal fat
- From:
Chinese Journal of General Practitioners
2019;18(11):1081-1084
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of 96 patients with type 2 diabetes mellitus (T2DM) treated in Department of endocrinology of our hospital from January 2016 to December 2017 were retrospectively analyzed. All patients had been treated with metformin ≥1 000 mg combined with sulfonylureas for>12 weeks and their glycosylated hemoglobin (HbA1c) was>7.5%. On the basis of the original scheme, 57 patients received oral sitagliptin (100 mg q.d, sitagliptin group) and 39 patients received insulin glargine injection (insulin group) for 26 weeks. The blood lipid, liver and kidney function were examined before and after treatment. The abdominal visceral fat area (VFA) was measured by CT scan. Results showed that the fasting plasma glucose (FPG) , 2-hour postprandial blood glucose (2 hPG) and HbA1c were significantly lower than baseline levels in both groups(P<0.05). The decrease of VFA in sitagliptin and insulin groups was by 9.6 (1.4,19.6)cm2 and by 8.3(-2.2,26.8) cm2, respectively; there was significant difference in variation of VFA before and after treatment between the two groups (P<0.05). There was no significant difference in blood pressure, liver function (ALT, AST) and estimated glomerular filtration rate (eGFR) before and after treatment in the sitagliptin group (P>0.05). Additional sitagliptin administration can effectively and safely reduce HbA1c and decrease the abdominal visceral fat content in T2DM patients who failed to metformin and sulfonylureas combined therapy.
