Neurocognitive Function and Health-Related Quality of Life in Pediatric Korean Survivors of Medulloblastoma.
10.3346/jkms.2016.31.11.1726
- Author:
Hee Jung YOO
1
;
Hyery KIM
;
Hyeon Jin PARK
;
Dong Seok KIM
;
Young Shin RA
;
Hee Young SHIN
Author Information
1. Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Medulloblastoma;
Survivors;
Cognition;
Quality of Life;
Korea
- MeSH:
Cognition;
Cognition Disorders;
Craniospinal Irradiation;
Diagnosis;
Drug Therapy;
Executive Function;
Follow-Up Studies;
Humans;
Intelligence;
Korea;
Medulloblastoma*;
Memory;
Parents;
Proxy;
Quality of Life*;
Survivors*
- From:Journal of Korean Medical Science
2016;31(11):1726-1734
- CountryRepublic of Korea
- Language:English
-
Abstract:
The neurocognitive function and quality of life of 58 Korean survivors of childhood medulloblastoma were assessed after surgery, cranial radiation and chemotherapy. All patients were evaluated with a battery of neurocognitive function tests and the Pediatric Functional Assessment of Cancer Therapy-Brain Tumor Survivors, which consists of self-report questionnaires on quality of life. The mean full-scale intelligence quotient (IQ), verbal IQ, and performance IQ scores were 90.2, 97.1, and 84.16, respectively. The mean memory quotient (MQ) score was 86.78, which was within 1 standard deviation of the average score of 100. Processing speed, attention, and executive function showed mild to moderate deficits. Intelligence, memory, executive function, visuospatial function, and simple motor function were significantly lower in the patients diagnosed before 8 years of age compared with those diagnosed after 8. The cognitive deficits in the patients diagnosed at younger ages might be related to earlier exposure to craniospinal irradiation and chemotherapy. The patient and parent proxy evaluations of attention, fine motor function, and quality of life did not differ. We found significant neurocognitive changes in a wide range of neurocognitive functional domains in Korean survivors of childhood medulloblastoma. Long-term follow-up studies of survivors of childhood medulloblastoma beginning at the time of their first diagnosis are required to better understand the deficits exhibited by survivors of childhood medulloblastoma, so that intervention strategies and treatment refinements that reduce the long-term neurocognitive decline can be developed.
