Epidemiological and clinical features of dengue fever outbreak in Jiangxi Province in 2019
10.3760/cma.j.issn.1000-6680.2019.11.001
- VernacularTitle: 2019年江西省登革热暴发疫情的流行病学及临床特征分析
- Author:
Hongyi CHEN
1
;
Yi ZHANG
2
;
Jingwen AI
2
;
Jingen WANG
3
;
Qiubo CHEN
3
;
Feibing LUO
4
;
Chengyun YANG
5
;
Jing WU
2
;
Yang ZHOU
2
;
Xinyu WANG
2
;
Ning JIANG
2
;
Shumei WANG
1
;
Wenhong ZHANG
2
Author Information
1. Department of Infectious Diseases, The Ninth Hospital of Nanchang, Nanchang 330002, China
2. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China
3. Department of Infectious Diseases, Zhangshu People′s Hospital, Yichun City, Jiangxi Province 331200, China
4. Department of Infectious Diseases, Fengcheng People′s Hospital, Jiangxi Province 331100, China
5. Department of Infectious Diseases, Nanchang County People′s Hospital, Nanchang 330200, China
- Publication Type:Journal Article
- Keywords:
Dengue;
Disease outbreaks;
Epidemiology;
Clinical manifestations
- From:
Chinese Journal of Infectious Diseases
2019;37(11):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the epidemiological and clinical characteristics of 91 cases of dengue fever outbreak in Jiangxi Province in 2019, and to strengthen the management and prevention of dengue fever.
Methods:The clinical data, laboratory results and etiology tests of 91 patients with dengue fever from the Ninth Hospital of Nanchang, Zhangshu People′s Hospital, Fengcheng People′s Hospital and Nanchang County People′s Hospital from July 31, 2019 to September 27, 2019 were retrospectively collected. The t test was used for continuous variables and chi-square test was used for categorical variables.
Results:A total of 91 dengue fever patients were reviewed. The patients age ranged from 4 to 87 years old, and the majority were adult patients. Most patients were farmers and they all had mosquito-biting history. Local cases were the major source of this outbreak. The incubation time was (5.19±2.96) days. All patients had fever over 38 ℃. Thirty-eight (41.8%) patients developed rashes, mainly distributed on the limbs and trunk, and 15 patients (16.5%) developed myalgia and fatigue. The incidence of rashes in patients admitted in September was 15.9% (7/44), which was significantly lower than 68.1% (32/47) in July and August (χ2=25.262, P<0.01). The incidence of headache in patients admitted in September was 27.3%(12/44), which was significantly lower than 78.7% (37/47) in July and August (χ2 =24.206, P<0.01). Among the 91 patients, 64 (70.3%) patients had white blood cell counts less than 4×109/L, 14(15.4%) patients had platelet counts less than 50×109/L. The positive rate of dengue non-structural protein 1 (NS1) antigen was 100.0%(37/37), the positive rates of dengue antibody IgM and IgG were 50.0%(11/22) and 13.6%(3/22), respectively. Among the 113 serum samples tested for dengue virus RNA, 106 were identified with dengue virus type-1 and two were dengue virus type-2. In 22 patients who received tests within 7 days, the positive rate of NS1 antigen was 100.0% (22/22), the IgM and IgG positive rates were 50.0%(11/22) and 13.6% (3/22), respectively, and 19 patients were infected with dengue type-1. Among the IgM antibody positive cases, the onset days before sampling was (5.09±1.64) days, longer than that of IgM antibody negative cases ((2.82±1.83) days), with statistical significance (t=3.063, P=0.007). The onset time before sampling in dengue virus RNA-positive group was (3.53±1.87) days, which was shorter than that of RNA-negative group ((6.67±0.58) days), and the difference was statistically significant (t=2.839, P=0.013).
Conclusions:The dengue fever outbreak cases in Jiangxi Province in 2019 have typical clinical manifestations of dengue fever. Using the NS1 antigen test, IgM and IgG antibody tests and real-time fluorescent quantitative polymerase chain reaction for dengue virus genotyping during early onset of the disease can assistant clinicians in clinical management, controlling infectious source and stopping disease transmission.
