Application progress of transcriptome sequencing in hematological malignancies

VernacularTitle: 转录组测序在血液肿瘤中的应用进展
Author: Hongxing LIU ¹ ; Xue CHEN ² ; Fang WANG ² ; Xiaoli MA ² ; Lili YUAN ² ; Panxiang CAO ² ; Daijing NIE ²
Author Information

1. Beijing Lu Daopei Institute of Hematology, Beijing 100076, China
2. Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang 065201, China
Publication Type:Review
Keywords: High-throughput nucleotide sequencing; Transcriptome; Gene sequencing; Fusion genes; Gene mutations; Hematological malignancies
From: Journal of Leukemia & Lymphoma 2019;28(12):705-708
CountryChina
Language:Chinese
Abstract: Transcriptome sequencing (RNA-seq) has unique advantages in analyzing gene fusion, splicing mutations, and gene expression profiles. Single-cell RNA-seq provides powerful tools to reveal cellular heterogeneity in normal and tumor tissues. With the widespread application of high-throughput gene sequencing technology and the rapid reduction in cost, RNA-seq is increasingly used in hematological malignancies research. This article introduces the related research progress in conjunction with reports at the 61st American Society of Hematology Annual Meeting.