Correlation between serum homocysteine and early neurological deterioration in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.12.002
- VernacularTitle: 血清高半胱氨酸与急性缺血性卒中患者早期神经功能恶化的相关性
- Author:
Shukang YU
1
;
Yu JIN
Author Information
1. Third Ward, Department of Neurology, Bozhou People's Hospital, Bozhou 236800, China
- Publication Type:Clinical Trail
- Keywords:
Stroke;
Brain ischemia;
Homocysteine;
Disease progression;
Risk factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2019;27(12):886-890
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the level of serum homocysteine (Hcy) and early neurological deterioration (END) in patients with acute ischemic stroke.
Methods:From June 2018 to August 2019, consecutive patients with acute ischemic stroke within 24 h of onset admitted to Bozhou People's Hospital were enrolled retrospectively. Their baseline cilinical data, imaging and laboratory findings were collected. END was defined as the National Institutes of Health Stroke Scale (NIHSS) score increased ≥2 or the motor item score increased ≥1 within 72 h of onset compared with the baseline. Univariate analysis was used to compare the demography, vascular risk factors, baseline blood pressure, laboratory findings, etiological typing of stroke, stroke distribution and the time from onset to admission between the END group and non-END group. Multivariate logistic regression analysis was used to identify the independent risk factors for END.
Results:A total 112 patients with acute ischemic stroke were enrolled, among them, 29 (25.9%) occurred END. Univariate analysis showed that there were significant differences in baseline NIHSS score (Z=4.653, P<0.001), C-reactive protein (CRP) (t=2.437, P=0.017), fasting blood glucose (t=2.781, P=0.006), Hcy (t=3.932, P<0.001) and glycated hemoglobin (t=2.107, P=0.047) between the END group and the non-END group. Multivariate logistic regression analysis showed that high baseline NIHSS score (odds ratio [OR] 1.566, 95% confidence interval [CI] 1.237-1.982; P=0.015), CRP >10 mg/L (OR 3.138, 95% CI 1.871-5.362; P=0.030), fasting blood glucose >6.1 mmol/L (OR 2.529, 95% CI 1.736-4.651; P=0.027), and Hcy >15 μmol/L (OR 3.542, 95% CI 1.295-9.461; P=0.038) were the independent risk factors for END in patients with acute ischemic stroke.
Conclusion:The elevated baseline serum Hcy level was an independent risk factor for END in patients with acute ischemic stroke.
