The Risk for Insulin Resistance according to the Degree of Non-Alcoholic Fatty Liver Disease in Korean Men.
10.3346/jkms.2016.31.11.1761
- Author:
Jae Hong RYOO
1
;
Hyun Pyo HONG
;
Sung Keun PARK
;
Woo Taek HAM
;
Ju Youn CHUNG
Author Information
1. Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Non-Alcoholic Fatty Liver Disease;
Insulin Resistance;
HOMA-IR;
HOMA-ß
- MeSH:
Homeostasis;
Humans;
Incidence;
Insulin Resistance*;
Insulin*;
Male;
Non-alcoholic Fatty Liver Disease*;
Proportional Hazards Models;
Risk Factors
- From:Journal of Korean Medical Science
2016;31(11):1761-1767
- CountryRepublic of Korea
- Language:English
-
Abstract:
Insulin resistance (IR) plays a significant role in the development and progression of non-alcoholic fatty liver disease (NAFLD). However, the natural course of insulin sensitivity under NAFLD remained unclear. Accordingly, this study was designed to investigate the effect of NAFLD on insulin resistance. A total of 20,628 Korean men without homeostasis model assessment of insulin resistance (HOMA-IR < 2.7) were followed-up for 5 years. They were serially checked for HOMA-IR to monitor the development of IR (HOMA-IR ≥ 2.7). The incidence rate of IR increased according to the degree of NAFLD (normal: 11.6%, mild: 28.8%, moderate to severe: 40.5%, P < 0.001). Cox proportional hazards model showed that HRs (95% CI) for IR increased proportionally to the degree of NAFLD (mild: 1.19 [1.02–1.39], moderate to severe: 1.32 [1.08–1.57]). IR was more potentially associated with the more progressive NAFLD than normal and milder state. In addition, NAFLD was the independent risk factor of the development of IR. These results suggest the potential availability of NAFLD as a predictor of IR.
