Progress of astrocytes and their exosomes in central nervous system disease
10.3760/cma.j.issn.1673-4408.2019.12.014
- VernacularTitle: 星形胶质细胞及其外泌体在中枢神经系统疾病中的研究进展
- Author:
Danrui DING
1
;
Hua WANG
Author Information
1. Department of Pediatric Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Review
- Keywords:
Astrocyte;
Exosome;
Central nervous system disease
- From:
International Journal of Pediatrics
2019;46(12):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Astrocytes exist in the central nervous system widely, through cell-cell communication in neurovascular units, playing an important role in providing metabolic support for neurons, regulating nerve function and plasticity and so on.There is evidence that exosomes play a key regulatory role in intercellular communication by carrying natural cargo molecules and participate in a variety of pathophysiological processes.However, the role of astrocyte-derived exosome in central nervous system diseases is largely unknown.In this paper, the classification, characteristics, biomarkers, physiological functions, functions of astrocyte-derived exosome and their roles in central nervous system diseases are reviewed, for a deeper understanding of the role of astrocytes in central nervous system diseases.
