The effects of microRNA on osteogenesis
10.3760/cma.j.issn.1673-4408.2019.12.009
- VernacularTitle: 微小RNA对骨生成影响的研究进展
- Author:
Wenpeng XUE
1
;
Wenting LUO
;
Qun ZHAO
Author Information
1. Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Review
- Keywords:
MicroRNA;
Osteogenesis;
Osteogenic differentiation;
Signal pathway;
Cytokine
- From:
International Journal of Pediatrics
2019;46(12):891-895
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is an endogenous, non-coding single-stranded RNA that regulates a variety of signal pathways or cytokines.Recent studies have confirmed that miRNA can affect alkaline phosphatase activity and matrix mineralization in bone formation, and plays an important role in osteogenic differentiation and cartilage differentiation.Abnormalities in the osteogenesis process can lead to osteogenesis imperfecta, Feingold syndrome, and femoral head necrosis.This review summarizes the specific mechanism of osteogenic differentiation and cartilage differentiation regulated by miRNA, suggesting the new clue for the future research about the underlying mechanism of bone development and clinical treatment of bone dysplasia from epigenetics.
