Current research on pathogenesis and early diagnosis of necrotizing enterocolitis
10.3760/cma.j.issn.1673-4408.2019.12.005
- VernacularTitle: 新生儿坏死性小肠结肠炎发病机制与早期诊断研究进展
- Author:
Chao WANG
1
;
Xueping ZHU
Author Information
1. Department of Neonatology, Children′s Hospital of Soochow University, Suzhou 215025, China
- Publication Type:Review
- Keywords:
Necrotizing enterocolitis;
Pathogenesis;
Early diagnosis;
Preterm infants
- From:
International Journal of Pediatrics
2019;46(12):874-878
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal necrotizing enterocolitis(NEC)is an inflammatory intestinal disorder that seriously threatens the life of neonates(especially premature babies). The pathogenesis of NEC remains uncertain.The main factors thought to be connected with the pathogenesis of NEC are: intestinal immaturity, enteral feeding, the intestinal microecological imbalance, inflammation, ischaemia-reperfusion injury and genetic predisposition.The clinical manifestations of NEC are diversified and early symptoms are concealed.It is easy to be misdiagnosed or missed, delayed treatment.Imaging techniques such as abdominal X-ray or ultrasound, intestinal microbiome and its metabolites determination, biomarkers and other methods contribute to early diagnosis.This article reviews the advances in the pathogenesis and early diagnosis of NEC to guide clinical prevention and treatment.
