Optimization of extraction technology for Gegen-Shujin granules with orthogonal test
10.3760/cma.j.issn.1673-4246.2019.12.018
- VernacularTitle: 正交试验优选葛根舒筋颗粒提取工艺
- Author:
Yue XIE
1
;
Qi LIANG
1
;
Liping CAO
1
;
Zilong ZHANG
1
;
Yulin FENG
2
Author Information
1. Chinese Medicine Application Research Center, Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, Shenzhen 518000, China
2. National Engineering Research Center for solid preparation manufacturing technology of traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
- Publication Type:Journal Article
- Keywords:
Volatile oils;
Puerarin;
Orthogonal test;
Extraction;
Gegen-Shujin granules;
Quality control;
Dosage forms improving
- From:
International Journal of Traditional Chinese Medicine
2019;41(12):1365-1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the extraction technology for Gegen-Shujin granules.
Methods:With yield of volatile oil as index, single factor tests were used to investigate effects of water, soaking time and distillation time on extraction technology of volatile oil. The water amount, extraction time and numbers of extraction as factors, the contents of puerarin and total solid as indexes, orthogonal test was employed to optimize the extraction technology of Gegen-Shujin granules.
Results:The optimical extraction technology conditions were as follows: Cinnamomi Ramulus, cinnamomi ramulus, notopterygium, turmeric were extracted to get volatile oil with eight-folds amount water of herbs for 6 hours; while the other herbs were boiled with ten-folds amount water of herbs and extrancted for two times, 1.5 hours each time.
Conclusions:This extraction process is reasonable and practical, and can guarantee the quality of preparation.
