Treatment and improvement of scar hyperplasia by panax notoginseng based on network pharmacology study on molecular mechanisms
10.3760/cma.j.issn.1673-4246.2019.12.016
- VernacularTitle: 基于网络药理学的三七治疗和改善瘢痕增生分子机制研究
- Author:
Jingwen HUANG
1
;
Xue HAN
;
Xu ZHAO
;
Xubo LI
;
Xingzhong DONG
;
Lifeng AN
;
Shunxin JI
;
Xianghe XIA
Author Information
1. Jiamusi College, Heilongjiang University of Traditional Chinese Medicine, Jiamusi 150040, China
- Publication Type:Journal Article
- Keywords:
Panax notoginseng;
Cicatrix;
Network pharmacology;
Target;
Signaling pathway
- From:
International Journal of Traditional Chinese Medicine
2019;41(12):1353-1359
- CountryChina
- Language:Chinese
-
Abstract:
Objective:We predicted the molecular mechanism of Panax notoginseng in the treatment and improvement of scar hyperplasia, by using the methods of network pharmacology and bioinformatics.
Methods:We collected of related active constituents and targets of Panax notoginseng by retrieving TCM systems pharmacology database and analysis platform (TCMSP), and collected of related active constituents and targets of scar by Genecards database and OMIM database. Cytoscape 3.6.1 software was used to construct "drugs-chemical components-targets-diseases" interaction network diagram. The protein in teraction network map (PPI) was constructed by STRING database. The key targets were used to analyze gene ontology (GO) enrichment and kyoto encyclopedia of genes and genome (KEGG) pathway enrichment.
Results:Totally 7 chemical compponents, including beta-sitosterol, quercetin, Stigmasterol and etc. and 108 targets, including AKT1, JUN, MAPK1, IL6 and ect. Panax notoginseng exerts its effects on scar mainly by acting on signal pathways, including PI3K-AKt signal pathway, MAPK signal pathway, TNF signal pathway and ect.
Conclusions:Based on the methodology of network pharmacology, this study preliminarily predicted the major targets and pathways Panax notoginseng in the treatment of scar, providing a direction for further studies.
