Effect of comfrey cream combined with NB-UVB on skin barrier function and immune function in the patients with psoriasis vulgaris
10.3760/cma.j.issn.1673-4246.2019.12.009
- VernacularTitle: 紫草乳膏外用联合窄谱中波紫外线对寻常型银屑病皮肤屏障及免疫功能的影响
- Author:
Jie SU
1
;
Zuping ZENG
;
Jing ZHANG
;
Xi JIANG
;
Yuanyuan WU
Author Information
1. Department of Dermatology, Beijing Traditional Chinese Medicine Hospital, Capital Madical University, Beijing 100010, China
- Publication Type:Clinical Trail
- Keywords:
Psoriasis;
Comfrey cream;
Narrow band ultraviolet;
Skin barrier function;
Immune function;
Therapies, investigational
- From:
International Journal of Traditional Chinese Medicine
2019;41(12):1318-1322
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of comfrey cream combined with narrow-band UVB (NB-UVB) on skin barrier function and immune function in the patients with psoriasis vulgaris.
Methods:A total of 100 patients with psoriasis vulgaris admitted from March 2016 to June 2017 were enrolled in the study. They were randomly divided into observation group (Purple Cream + NB-UVB) and control group (NB- UVB), 50 cases in each group. Psoriasis lesion area and severity index (PASI) and degree of pruritus were evaluated before treatment, after 2 weeks and 4 weeks of treatment. The skin barrier function and immune related indicators were compared between the two groups before and after the treatment.
Results:After treatment, the PASI score and pruritus score of the observation group and the control group showed a decreasing trend, and the observation group decreased more significantly. The interaction between the two groups at different time points, and between groups and at different time points were statistically significant (t values were 3.462, 2.833, P<0.05). After treatment, the water content of the stratum corneum (54.34% ± 5.04% vs. 49.03% ± 5.26%, t=5.154) and the sebum content (143.03 ± 11.60 μg/cm2 vs. 130.79 ± 14.54 μg/cm2, t=4.653) in the observation group were higher than those in the control group, and the transepidermal water loss (TEWL) [15.87 ± 4.22 g/(h•m2) vs. 19.87 ± 3.06 g/(h•m2), t=5.426] in the observation group was lower than that in the control group (P<0.05). The CD4+ (42.06% ± 4.68% vs. 33.01% ± 3.07%, t=11.433), CD4+/CD8+ (20.89 ± 3.44 vs. 26.03 ± 3.44, t=8.209) in observation group and control group were increased after treament, while CD8+(1.89% ± 0.29% vs. 1.43% ± 0.27%, t=7.471) was decreased, the observation group was superior to the control group (P<0.05).
Conclusions:Treatment of vulgaris vulgaris with comfrey cream combined with NB-UVB can improve symptoms and improve skin barrier function and immune function.
