Advances on the mechanism of caffeine in preventing bronchopulmonary dysplasia in preterms
10.3760/cma.j.issn.1673-4912.2019.12.013
- VernacularTitle: 咖啡因预防早产儿支气管肺发育不良作用机制研究进展
- Author:
Jun LI
1
;
Jianhua FU
Author Information
1. Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Review
- Keywords:
Caffeine;
Bronchopulmonary dysplasia;
Preterm
- From:
Chinese Pediatric Emergency Medicine
2019;26(12):941-946
- CountryChina
- Language:Chinese
-
Abstract:
Caffeine citrate, as one type of methylxanthine, is often used to treat apnea in premature infants.Recent studies have found that it is not only used for extubation before weaning, shortening the time of mechanical ventilation, preventing apnea and reducing the occurance of intermittent hypoxic episodes, but also exerting lung protection by inhibiting inflammatory reactions, mitigating oxidative stress, improving pulmonary function and pulmonary angiogenesis.Thus, it could effectively reduce the risk of bronchopulmonary dysplasia in premature infants.
