Effects of full-course epidural delivery on puerpera and neonatal
10.3760/cma.j.issn.1008-6706.2019.12.011
- VernacularTitle: 全程硬膜外麻醉分娩镇痛对产妇及新生儿的影响
- Author:
Yiyao HAN
1
;
Lieping HUANG
1
;
Yuxin TANG
2
;
Lanfeng CHEN
3
;
Min BAI
1
Author Information
1. Department of Pediatrics, Zhoushan Maternal and Child Health Hospital, Zhoushan Zhejiang 316000, China
2. Department of Obstetrics, Zhoushan Maternal and Child Health Care Hospital, Zhoushan Zhejiang 316000, China
3. Department of Anesthesia, Zhoushan Maternal and Child Health Hospital, Zhoushan Zhejiang 316000, China
- Publication Type:Journal Article
- Keywords:
Parturition;
Analgesia;
Anesthesia, epidural;
Pain;
Oxidative stress;
Apgar Score;
Infant, newborn
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(12):1454-1458
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of epidural analgesia on puerpera and neonatal.
Methods:A total of 150 puerpera were continuously enrolled from May 2017 to May 2018 in Zhoushan Maternal and Child Health Care Hospital, and were divided into analgesia group (102 cases) and non-analgesia group (48 cases) according to their prenatal wishes.The analgesia group was given epidural anesthesia for analgesic delivery, while the control group had no analgesia intervention.Differences in the expression of serum pain and stress hormones were compared between two groups at the time of prenatal, postpartum 1h and 24h.At the same time, differences in neonatal NACS scores were compared between two groups at the time of postpartum 1h, 8h and 24h.
Results:No statistically significant differences were found between the two groups in prenatal serum pain and stress hormones, but at the time of postpartum 1h and 24h, serum pain media neuropeptide Y (NPY) (t=5.041, P=0.000; t=4.984, P=0.000), 5-hydroxytryptamine (5-HT) (t=3.083, P=0.002; t=4.203, P=0.000), prostate E2 (PGE2) (t=6.764, P=0.000; t=4.364, P=0.000) and stress hormone angiotensin Ⅱ (AngⅡ) (t=3.670, P=0.000; t=2.911, P=0.004), adrenocorticotropic hormone (ACTH)[(212.54±38.65) ng/mL vs.(231.43±34.82)ng/mL, t=3.510, P=0.001; (163.82±33.21) ng/mL vs.(175.21±32.48) ng/mL, t=2.105, P=0.045)]and cortisol (Cor)[(344.56±57.39) μg/L vs.(381.81±59.23)μg/L, t=3.670, P=0.000; (241.27±43.44) μg/L vs.(262.56±37.97) μg/L, t=2.911, P=0.004)] in the analgesia group were significantly lower than those in the non-analgesia group.There were no statistically significant differences in NACS score, complications and Apgar score between the two groups (all P>0.05).
Conclusion:The analgesic effect of full-course epidural delivery in analgesic delivery is remarkable, which can effectively reduce maternal stress reaction, and it is safe and has less adverse effect on neonates.
