The clinical significance of diagnosis and therapy in patients with adult bronchial asthma by fractional exhaled nitric oxide levels
10.3760/cma.j.issn.1008-6706.2019.12.003
- VernacularTitle: 呼出气一氧化氮测定在成人支气管哮喘诊治中的临床意义
- Author:
Cuicui CHEN
1
;
Yi CAO
;
Aiguo FU
;
Liang ZHANG
;
Weiqiang HU
;
Tongbing WANG
Author Information
1. Department of Respiration, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, He′nan 471000, China
- Publication Type:Journal Article
- Keywords:
Asthma;
Nitric oxide;
Respiratory function tests;
Oxyphil cells;
Granulocytes;
Glucocorticoids;
Adult
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(12):1419-1423
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the sensitivity and specificity of exhaled nitric oxide in the diagnosis and therapy of bronchial asthma.
Methods:From January 2016 to December 2017, 87 patients diagnosed with bronchial asthma in Luoyang Central Hospital Affiliated to Zhengzhou University were selected as asthma group , and 40 healthy people were selected as healthy control group at the same term.The levels of FeNO, FEV1/pred, peripheral blood EOS count, ACT score, percentage of sputum EOS were measured.
Results:The positive rate of FeNO was 56.3%(49/87) in the asthma group, which in the healthy control group was 5.0%(2/47). The fractional exhaled nitric oxide level of reexamined patients before treatment [(70.9±53.6)ppb] was higher than that after treatment[(12.2±8.7)ppb], and the difference was statistically significant(t=4.323, P=0.001). The fractional exhaled nitric oxide level in the asthma group [(42.4±42.5)ppb] was higher than that in the healthy control group [(9.4±5.8)ppb], and the difference between the two groups was statistically significant(t=2.871, P=0.001). The fractional exhaled nitric oxide level was positively correlated with peripheral blood EOS count (r=0.376, P=0.000) and ACT score (r=0.361, P=0.001), but had no correlation with FEV1/pred (r=-0.111, P=0.306) and sputum EOS (r=-0.036, P=0.805).
Conclusion:The measurement of fractional exhaled nitric oxide levels has an important clinical significance in the diagnosis of bronchial asthma.And it has a guiding significance for the evaluation of the therapeutic effect of bronchial asthma.
