Predictive value of protein C for long-term mortality of patients with community-acquired pneumonia
10.3760/cma.j.issn.1008-6706.2019.12.001
- VernacularTitle: 蛋白C对社区获得性肺炎患者长期病死率的预测价值
- Author:
Wenyang WANG
1
;
Chaoqun WANG
;
Yi LI
;
Fan BU
;
Qiang FENG
Author Information
1. Department of Clinical Laboratory, Taian Central Hospital, Taian, Shandong 271000, China
- Publication Type:Journal Article
- Keywords:
Pneumonia;
Community-acquired infections;
Protein C;
Mortality;
Forecasting;
Risk factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(12):1409-1414
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of protein C(PC) for long-term mortality of patients with community-acquired pneumonia(CAP).
Methods:A total of 657 patients with CAP were enrolled in Taian Central Hospital from January 2011 to December 2011.The patients were divided into short-term group(≤30 days), medium-term group(>30~90 days) and long-term group(>90 days). PC, high sensitivity C-reactive protein(hs-CRP), procalcitonin(PCT), pneumonia severity index(PSI) score and CURB-65 score were measured at the time of admission.The ROC curve was used to evaluate the independent risk factors.The Kaplan-Meier survival function curve was used to analyze the difference of mortality between the short-term group and long-term group.Independent risk factors for CAP risk were analyzed by COX regression.
Results:A total of 597 cases were followed up, there were 49 cases(8.09%) in the short-term group, 11 cases(1.84%) in the medium-term group, and 537 cases(89.93%) in the long-term group.The PC levels in the short-term group, medium-term group and long-term group were (32.2±10.6)%, (43.1±9.9)%, (69.6±23.0)%, respectively.The level of PC was significantly increased in the short-term group compared with the medium-term group and long-term group (short-term group vs.medium-term group, q=6.18, P<0.05, short-term group vs.long-term group, q=9.87, P<0.05). The hs-CRP levels in the short-term group, medium-term group and long-term group were (108.1±22.4)mg/L, (68.2±12.9)mg/L, (25.1±17.1)mg/L, respectively.The level of hs-CRP was significantly increased in the short-term group compared with the medium-term group and long-term group (short-term group vs.medium-term group, q=5.23, P<0.05, short-term group vs.long-term group, q=12.95, P<0.05). Meanwhile, PC showed higher accuracy(AUC, 0.889) than CURB-65(AUC, 0.828) and hs-CRP(AUC, 0.711) in the long-term group.The Kaplan-Meier survival function curve showed that the mortality rate was significantly higher in the high-value group compared with the low-value group(F=17.10, P<0.01). PC was an independent factor for long-term mortality and was associated with poorer survival by the COX regression analysis.
Conclusion:PC has a high predictive value for long-term mortality in CAP patients.
