The value of combined detection of serum precalcitonin, prealbumin and retinol-binding protein in the early diagnosis of sepsis
10.3760/cma.j.issn.1673-4904.2019.12.009
- VernacularTitle: 联合检测血清降钙素原、血清前白蛋白和视黄醇结合蛋白对脓毒血症早期诊断的价值
- Author:
Huilan WU
1
;
Chunfen MAO
;
Xiaojun CHEN
Author Information
1. Department of Pediatrics, Taizhou Hospital of Zhejiang Province, Zhejiang Taizhou 317000, China
- Publication Type:Journal Article
- Keywords:
Sepsis;
Prealbumin;
Retinol-binding proteins;
Child;
Precalcitonin
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(12):1093-1096
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical diagnosis value of serum precalcitonin(PCT) and early predictive significance of prealbumin (PA) and retinol-binding protein (RBP) in liver and renal injury for sepsis in children.
Methods:One hundred and fifty sepsis children were enrolled from the ward of children in Taizhou Hospital of Zhejiang Province from January 2018 to August 2019. In the same period 150 children with common infection and 150 healthy children who underwent physical examination were included into the study. According to the test, basic data was collected, and biochemical examinations, including the concentrations of the liver function, renal function, PA and RBP were measured. Then the data in the three groups was analyzed.
Results:The levels of PCT in sepsis group were significantly higher than those in the common infection group and the normal group: (7.02 ± 5.26) μg/L vs. (0.37 ± 0.28), (0.03 ± 0.01) μg/L; the levels of PA and RBP in sepsis group were significantly lower than those of the other two groups: (9.31 ± 4.36) mg/dl vs. (31.05 ± 5.05), (33.56 ± 4.59) mg/dl; (9.26 ± 3.58) mg/L vs. (31.2 ± 5.89), (33.83 ± 6.31) mg/L, and there were significant statistical differences (P < 0.05). The levels of PA and RBP in the common infection group and the normal group were normal and there was no difference between the two groups (P > 0.05). There were no significant statistical differences in other indicators such as alanine aminotransferase, asparagus cochinchinensis, albumin, urea nitrogen and creatinine (P > 0.05).
Conclusions:Combined detection of serum PCT, PA and RBP plays an important role in the early diagnosis of children′s sepsis.
