Clinical significance of the serum to urinary thioredoxin ratio for diagnosis and prediction of the severe acute pyelonephritisin children
10.3760/cma.j.issn.1673-4904.2019.12.005
- VernacularTitle: 血清与尿硫氧还原蛋白比值对儿童急性肾盂肾炎诊断及病情预测价值
- Author:
Mingzhu LYU
1
;
Quanjing CHEN
;
Zhigang ZHA
;
E MEI
Author Information
1. Children′s Medical Center, Dongfeng Hospital of Hubei University Medicine, Hubei Shiyan 442001, China
- Publication Type:Journal Article
- Keywords:
Thioredoxin;
Pyelonephritis;
Children;
Diagnosis
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(12):1076-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic and predictable value of the levels of serum Trx (S-Trx), urinary Trx (U-Trx) and S-Trx/U-Trx ratio in acute pyelonephritis of children.
Methods:A total of 120 children with urinary tract infection were divided into APN group (67 cases) and non-APN group (53 cases).In addition, 67 children with APN were assigned to severe group (23 cases)and non-severe group (44 cases). The leves of serum C-reactive protein(CRP), precalcitonin(PCT), cystatin C (CysC), Trx (S-Trx) and urinary β2-microglobulin(β2-MG), neutrophill gelatinase-related apolipoprotein (NGAL), Trx (U-Trx) were collected. Besides, the ratio of S-Trx/U-Trx was also counted. The diagnostic and predictable value of each index were determined by receiver operating characteristic (ROC).
Results:Serum PCT, S-Trx, urinary β2-MG, NGAL, U-Trx was markedly increased and S-Trx/U-Trx ratio was obviously decreased in the APN group compared to that of the non-APN group (P<0.05). Moreover, S-Trx, urinary NGAL, U-Trx was significantly increased and S-Trx/U-Trx ratio was significantly decreased in the severe group compared to that of the non-severe group (P<0.05). Both in APN group or severe APN group, S-Trx and U-Trx displayed significantly positive correlation (P<0.05). The results from ROC demonstrated that AUC were 0.960, and optimal cut-off value were 16.17 μg/L of U-Trx diagnostic APN in children, with a specificity and sensitivity of 94.34% and 92.54%, respectively. The optimal cut-off value was 1.29.AUC of S-Trx/U-Trx 0.960 predicted the severe of APN in children, with a specificity and sensitivity of 81.82% and 82.61%, respectively.
Conclusions:U-Trx is useful for diagnostic APN in children, S-Trx/U-Trx is an independent predictor of the severe APN.
