The effect of color Doppler ultrasound combined with serum CA125 level on the diagnostic efficacy of patients with ovarian cancer
10.3760/cma.j.issn.1008-1372.2019.12.021
- VernacularTitle: 彩色多普勒超声联合血清CA125水平检测对卵巢癌患者的诊断效能
- Author:
Hongyuan JI
1
;
Huiyang SHI
2
;
Wanming CHEN
1
Author Information
1. Department of Ultrasound, Guangzhou Eighth People's Hospital, Guangzhou 510080, China
2. Department of Ultrasound, Guangdong Armed Police Corps Hospital, Guangzhou 510507, China
- Publication Type:Journal Article
- Keywords:
Ultrasonography, doppler, color;
CA-125 antigen;
Ovarian neoplasms
- From:
Journal of Chinese Physician
2019;21(12):1841-1844
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of color Doppler ultrasound (CDUS) combined with serum glucoside antigen 125 (CA125) on the diagnostic efficacy of patients with ovarian cancer.
Methods:A total of 78 patients with ovarian tumors admitted to our hospital from February 2012 to June 2018 were enrolled. Among them, 38 patients with malignant tumors and 40 patients with benign tumors were tested for CDUS and serum CA125. The characteristics of CDUS images and serum CA125 levels in patients with malignant tumors were analyzed by pathological examination as the gold standard. The diagnostic efficacy of CDUS combined with serum CA125 level detection and separate examination was analyzed.
Results:⑴ Characteristics of CDUS images: the size, location, texture, blood flow signal, resistance index, ascites, peritoneal implant nodule or enlarged lymph node of patients with malignant tumors were significantly different from those of benign tumors (P<0.05). ⑵ Serum CA125 level: the serum CA125 level of patients with malignant tumors was higher than that of patients with benign tumors (P<0.05). ⑶ Diagnostic results: among 78 patients with ovarian tumors, 33 cases of malignant tumors were detected by serum CA125, 45 cases of benign tumors, of which 5 cases were misdiagnosed, and 10 cases were missed. For example, CDUS detected 35 malignant tumors and 43 benign tumors, of which 6 were misdiagnosed and 9 were missed. A total of 43 malignant tumors and 35 benign tumors were detected, of which 6 were misdiagnosed and 1 was missed. ⑷ Diagnostic efficacy: the accuracy of CDUS combined with serum CA125 level detection (91.03%) was higher than that of the two groups (80.77% and 80.77%), but the difference was not statistically significant (P>0.05); the sensitivity of CDUS combined with serum CA125 level detection was 97.37%. The two were independently examined by 76.32% and 73.68% (P<0.05). The specificity of CDUS combined with serum CA125 was 85.00%, with no significant difference between the two groups (80.05%, 87.50%) (P>0.05).
Conclusions:The serum CA125 level of patients with ovarian cancer is abnormally elevated. The characteristics of CDUS images are different from those of benign tumors, which can effectively identify benign and malignant tumors. CDUS combined with serum CA125 level detection can significantly improve the diagnostic efficacy, and they can be used to judge the disease and symptom , and provide guidance for treatment and prognosis assessment.
