Long-term effect of neuroendoscopy followed by radiotherapy on cystic craniopharyngiomas
10.3760/cma.j.issn.1008-1372.2019.12.006
- VernacularTitle: 神经内镜后放疗治疗囊性颅咽管瘤的长期疗效研究
- Author:
Zhihui WANG
1
;
Xiaokun GENG
2
Author Information
1. Changsha Health Vocational College, Changsha 410100, China
2. Department of Neurology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing 101149, China
- Publication Type:Journal Article
- Keywords:
Craniopharyngioma;
Neuroendoscopy;
Stereotaxic techniques;
Radiotherapy
- From:
Journal of Chinese Physician
2019;21(12):1778-1782
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the long-term effect of neuroendoscopy followed by radiotherapy on cystic craniopharyngiomas.
Methods:Cystic craniopharyngiomas in 9 patients were treated with neuroendoscopic cyst aspiration and fenestration, followed by fractionated stereotactic radiotherapy (FSRT). The neuroendoscopic procedure focused on widening of cyst fenestration and extensive irrigation of the cyst contents. The collimator of FSRT ranged from 2.5 cm to 3.0 cm, and the target volume 1.1-43.8 cm3, dose per fraction 1.8 Gy, total dose 50.4 Gy.
Results:The median follow-up period was 72.9 months. Tumor control was achieved in 8 of 9 patients. Marked tumor volume reduction was obtained with the neuroendoscopic procedure alone at 6 months, 1 year, and 2 years. One recurrent case showed multilobulated cysts, and a second surgery was required 1 year after the treatment. Clinical symptoms such as headache and visual disruption were rapidly alleviated after the neuroendoscopic procedure. No new visual disturbances, endocrinopathy, or hypothalamic dysfunction was observed during follow up.
Conclusions:Stereotactic radiotherapy for cystic craniopharyngioma after endoscopic fenestration can effectively control the tumor for a long period of time, improve the clinical symptoms and avoid endocrine diseases.
