Clinical application of contrast-enhanced ultrasound combined with modified labeled method in locating sentinel lymph nodes of breast cancer
10.3760/cma.j.issn.1004-4477.2019.12.010
- VernacularTitle: 超声造影结合改良标记法定位乳腺癌前哨淋巴结的临床应用
- Author:
Yan ZHENG
1
;
Jie SUN
2
;
Mengshang HU
1
;
Lizhu HOU
1
;
Jianxia LIU
2
;
Fenglin DONG
1
Author Information
1. Department of Ultrasound, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
2. Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
- Publication Type:Clinical Trail
- Keywords:
Contrast-enhanced ultrasound;
Breast neoplasms;
Sentinel lymph node;
Biopsy
- From:
Chinese Journal of Ultrasonography
2019;28(12):1061-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of contrast-enhanced ultrasound combined with modified labeled method in labeling sentinel lymph nodes of breast cancer in comparison with nano-carbon stained method.
Methods:Eighty female breast cancer patients who underwent surgery in the First Affiliated Hospital of Soochow University between July 2017 and April 2019 were enrolled. Sentinel lymph nodes in all patients were labeled by contrast-enhanced ultrasound combined with modified labeled method and nano-carbon stained method, respectively. The consistency of first lymph node labeled by the two methods was judged, the number of SLNs labeled by two methods was counted, and the pathology of the labeled SLN was compared with that after axillary dissection.
Results:The two methods have good consistency in locating sentinel lymph nodes of breast cancer(Kappa=0.749, P=0.000). The number of SLNs labeled by modified labeling method was significantly less than that labeled by stained method(Z=-7.434, P=0.000). The pathology of lymph nodes labeled by both the modified labeling method and stained method coincided well with that of axillary dissection(Kappa=0.941, 0.943; P=0.000, 0.000), and diagnostic efficiency was comparable(AUC=0.964, 0.967).
Conclusions:Contrast-enhanced ultrasound combined with modified labeling method is simple and accurate in labeling sentinel lymph nodes of breast cancer. Accurate assessment of axillary lymph node staging can be made by precise biopsy of 1-2 SLNs.
