Study on the prediction of cervical lymph node metastasis risk in preoperative thyroid papillary carcinoma by ultrasonic elemental observation of thyroid nodules
10.3760/cma.j.issn.1004-4477.2019.12.008
- VernacularTitle: 甲状腺结节超声要素化观测对甲状腺乳头状癌术前颈淋巴结转移风险的预测研究
- Author:
Qian WANG
1
,
2
;
Yanyu LI
1
,
2
;
Jinduo SHOU
1
;
Leqi WANG
1
;
Jiaoni WANG
1
;
Li GAO
3
;
Deguang ZHANG
3
;
Gaofei HE
3
;
Gonglin FAN
4
;
Jiang ZHU
1
Author Information
1. Department of Diagnostic Ultrasound, Sir Run Run Shaw Hospital of Zhejiang University College of Medicine & Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, China
2. Department of Diagnostic Ultrasound, the First People′s Hospital of Linhai City, Linhai 317000, China
3. Department of Head Neck Surgery, Sir Run Run Shaw Hospital of Zhejiang University College of Medicine & Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, China
4. School of Medicine, Hangzhou Normal University, Hangzhou 310000, China
- Publication Type:Clinical Trail
- Keywords:
Ultrasonography;
Thyroid neoplasms;
Lymph node metastasis
- From:
Chinese Journal of Ultrasonography
2019;28(12):1050-1055
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the correlation between ultrasound features of papillary thyroid carcinoma (PTC) and lymph node metastasis by preoperative ultrasound elemental observation of thyroid nodules.
Methods:Three hundred and seventy-six patients who underwent primary thyroid surgery and confirmed by ultrasound and pathological data as single-focal PTC from Jannary to December 2017 in Sir Run Run Shaw Hospital of Zhejiang Univbersity College of Medicine were retrospectively analyzed. According to the presence or absence of lymph node metastasis, they were divided into central and lateral lymph node metastasis group and non-metastasis group. Independent risk factors for central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM) were analyzed by χ2 test and multivariate Logistic regression.
Results:Multivariate analysis showed that the posterior margin of the cancer was <0.25 cm from the posterior wall of the thyroid gland as an independent risk factor for CLNM (P=0.025). Compared with the tumor volume ≤0.38 cm3, the cancer volume >0.38 cm3 (P=0.000), was more prone to CLNM. And multivariate analysis showed that the anterior margin of the cancer was <0.17 cm (P=0.006) from the anterior thyroid capsule and the inner wall of the foci was <0.26 cm (P=0.014) as independent risk factors for LLNM. Compared with the maximum diameter of the tumor lesion ≤1 cm, the maximum diameter >2 cm (P=0.001) group was more prone to LLNM. Compared with the tumor volume ≤0.38 cm3, the tumor volume >0.38 cm3 (P=0.000) was more prone to LLNM.
Conclusions:The larger volume of single focal PTC carcinoma and the closer to the posterior thyroid capsule are independent risk factors for CLNM. The larger volume and diameter of single focal PTC, and the closer to the anterior and medial wall capsule are independent risk factors for LLNM.
