Effect of cognitive-behavior therapy combined with mirtazapine on clinical efficacy in patients with functional dyspepsia
10.3760/cma.j.issn.1674-6554.2019.12.009
- VernacularTitle: 认知行为疗法联合米氮平治疗功能性消化不良疗效的研究
- Author:
Yong LI
1
;
Xiaoyin CONG
1
;
Danjun HE
1
;
Yinghui LI
2
Author Information
1. Department of Clinical Psychology, Jiangsu Province Hospital, Nanjing 210029, China
2. Department of Psychosomatics and Psychiatry, Zhongda Hospital, Southeast University, Nanjing 210009, China
- Publication Type:Clinical Trail
- Keywords:
Functional dyspepsia;
Cognitive-behavior therapy;
Randomized single-blind controlled trials;
Emotional symptoms;
Gastrointestinal symptoms
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(12):1102-1107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD).
Methods:Totally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention.
Results:After 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05).
Conclusion:CBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function.
