Clinical features and laboratory data analysis of Aeromonas bacteremia with hematological diseases

Chunhui XU; Qingsong Lin; Yanxia Lyu; Guoqing Zhu; Zhiying Tian; Chao Wang; Fujun Sun; Hongjing Yao; Chuan Wang

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Clinical features and laboratory data analysis of Aeromonas bacteremia with hematological diseases

VernacularTitle: 血液系统疾病合并气单胞菌血流感染患者的临床及实验室特征
Author: Chunhui XU ¹ ; Qingsong LIN ¹ ; Yanxia LYU ¹ ; Guoqing ZHU ¹ ; Zhiying TIAN ¹ ; Chao WANG ¹ ; Fujun SUN ¹ ; Hongjing YAO ¹ ; Chuan WANG ¹
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1. Institute of Hematology & Blood Diseases Hospital, CAMS&PUMC, National Clinical Research Center for Hematological Disorders, Tianjin 300020, China
Publication Type:Journal Article
Keywords: Aeromonas; Bacteremia; Hematological diseases; Antibiotic; Skin and soft tissue infection
From: Chinese Journal of Hematology 2019;40(12):1035-1039
CountryChina
Language:Chinese
Abstract: Objective:To investigate the clinical and laboratory features of Aeromonas bacteremia in patients with hematological diseases, and provide evidence for the prevention and treatment of Aeromonas infection.
Methods:A retrospective study of patients with bloodstream infection of Aeromonas in our hospital from January 2014 to December 2018 was carried out. The clinical characteristics, antimicrobial susceptibility, infection seasons, antimicrobial therapy and evolution were analyzed.
Results:A total of 42 patients with hematological diseases had Aeromonas bloodstream infection within 5 years. Among them, 39 cases (92.9%) of bloodstream infection occurred in the stage of neutropenia. The median time of fever was 4 (1-27) d, 22 (52.4%) patients only had fever, 6 (14.3%) with gastrointestinal symptoms (abdominal pain, diarrhea, nausea, upper gastrointestinal bleeding) , 8 (19.0%) with pulmonary infection, 13 (31.0%) with skin and soft tissue infections. Seven patients (16.7%) died with skin and soft tissue infection. The resistance of Aeromonas to carbapenems was 68.3%-70.7%, while the resistance rate to cephalosporins, quinolones and aminoglycosides were less than 10%.
Conclusions:Aeromonas bacteremia in patients with hematological diseases mainly occur in the neutropenia stage, usually with symptom like fever. The mortality is increased when accompanied by skin and soft tissue infection. Antibiotic use should be based on susceptibility results, and avoid the use of carbapenems.