Analysis of risk factors for progression of acute kidney injury to acute kidney disease
10.3760/cma.j.issn.1001-7097.2019.12.007
- VernacularTitle: 基于临床诊断的急性肾损伤进展为急性肾脏病的危险因素分析
- Author:
Lulu LIANG
1
,
2
,
3
,
4
;
Yan LIANG
;
Dongwei LIU
;
Yingjin QIAO
;
Jiayu DUAN
;
Shaokang PAN
;
Guangpu LI
;
Zhenjie LIU
;
Zhangsuo LIU
Author Information
1. Department of Nephrology, the First Affiliated Hospital of Zhengzhou University
2. Research Institute of Nephrology, Zhengzhou University
3. Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province
4. Core Unit of National Clinical Medical Research Center of Kidney Disease, Zhengzhou 450052, China
- Publication Type:Clinical Trail
- Keywords:
Renal insufficiency;
Acute kidney injury;
Risk factors;
Acute kidney disease;
Prognosis
- From:
Chinese Journal of Nephrology
2019;35(12):922-928
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of clinically diagnosed acute kidney injury (AKI) patients progressing to acute kidney disease (AKD).
Methods:The clinical data of AKI patients admitted to the First Affiliated Hospital of Zhengzhou University from January 1, 2018 to December 31, 2018 were retrospectively analyzed. According to the outcome of the patients, AKI patients were divided into non-acute kidney disease (NAKD) group and AKD group. Clinical characteristics and laboratory data of two groups were compared. The risk factors of AKD in patients with AKI were analyzed by logistic regression, and then the receiver operating characteristic curve (ROC) was drawn to evaluate the predictive value of these risk factors.
Results:A total of 254 patients with AKI were enrolled, and 186 patients developed AKD with an incidence of 73.2%. The incidences of AKD in stage 1, stage 2 and stage 3 of AKI were 20.0%, 46.7% and 83.5% respectively. Multivariate logistic regression analysis showed increased peak serum creatinine (within 7 days after AKI diagnosis) (OR=2.561, 95% CI 1.584-4.140, P<0.001), proteinuria (OR=2.952, 95% CI 1.162-7.500, P=0.023) and increased intact parathyroid hormone (OR=1.757, 95%CI 1.104-2.797, P=0.017) were independent risk factors for progression to AKD in patients with AKI. The ROC showed that increased peak serum creatinine (within 7 days after AKI diagnosis) was an important predictor of AKD in patients with AKI (AUC=0.798, P<0.001).
Conclusion:Increased peak serum creatinine (within 7 days after AKI diagnosis), proteinuria and increased intact parathyroid hormone are independent risk factors for progression to AKD in patients with AKI, providing new evidences and ideas for clinical preventions and treatments of AKD.
