Effect of different surgical procedures of parathyroidectomy on secondary hyperparathyroidism: a meta-analysis
10.3760/cma.j.issn.1001-7097.2019.12.006
- VernacularTitle: 不同术式治疗继发性甲状旁腺功能亢进临床疗效的Meta分析
- Author:
Linsheng LYU
1
;
Shaomin LI
2
;
Yuqiu YE
2
;
Wentao HU
2
;
Xun LIU
2
Author Information
1. Operation Room, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
2. Department of Nephrology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Clinical Trail
- Keywords:
Hyperparathyroidism, secondary;
Parathyroidectomy;
Meta-analysis
- From:
Chinese Journal of Nephrology
2019;35(12):914-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of total parathyroidectomy and autotransplantation (TPTX+AT) and total parathyroidectomy (TPTX) on secondary hyperparathyroidism (SHPT).
Methods:PubMed, EMBASE and Cochrane library were searched from inception to June 2017 for relative studies, which were screened according to inclusion criteria. Meta-analysis of included study were conducted to compare the improvement of symptoms, persistent SHPT, recurrent SHPT, reoperation, hypoparathyroidism, duration of operation and hospitalization between TPTX+AT group and TPTX group.
Results:A total of 11 studies with 1212 patients were included. Results of meta-analyses showed no difference between TPTX+AT and TPTX regarding improvement of symptoms and persistent SHPT (RR=1.03, P=0.70; RR=0.81, P=0.67, respectively), but TPTX was associated with lower risks of recurrent SHPT and reoperation (RR=0.25, P<0.01; RR=0.19, P<0.01). Patients with TPTX had higher rate of hypoparathyroidism (RR=2.68, P<0.01) but shorter time of operation (MD=-17.3, P=0.01). Durations of hospitalization were similar between the two groups (MD=-0.06, P=0.98).
Conclusion:Compared with TPTX+AT, TPTX reduces the risks of recurrent SHPT, reoperation and operation time, but has higher risk of hypoparathyroidism.
