Observation of clinical effect of photodynamic therapy on oral leukoplakia in elderly patients
10.3760/cma.j.issn.0254-9026.2019.12.017
- VernacularTitle: 光动力疗法治疗老年口腔白斑病患者的疗效观察
- Author:
Jianqiu JIN
1
;
Yuxing ZHANG
;
Zhiyue LU
Author Information
1. Department of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
Aminolevulinic acid;
Photo chemo therapy;
Leukoplakia, oral
- From:
Chinese Journal of Geriatrics
2019;38(12):1395-1397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of photodynamic therapy on oral leukoplakia in elderly patients.
Methods:In this prospective study, fifteen elderly patients with oral leukoplakia were treated with 5-aminolevulinic acid-based photodynamic therapy(ALA-PDT). After 2 hours of dressing, patients were irradiated using a 635nm semiconductor laser with the power density of 300mW/cm2.Each lesion was irradiated for 6 minutes with energy density of 100J/cm2.The curative effect was evaluated and the adverse reactions were recorded based on the observation of lesion changes.
Results:Of the 15 lesions in 15 patients, 4 lesions were treated once, 3 lesions were treated twice.And 6 lesions were cured after three treatments, and 2 patients were cured after four treatments.The average treatment frequency was(2.4±1.1)treatment.The postoperative adverse reaction was pain.The average visual analogue scale was(2.2±0.8)scores after operation, and the duration of pain was(2.6±1.1)days after operation.There was no recurrence for 3 to 9 months after operation.No abnormalities of oral sensation and function were found in patients.
Conclusions:ALA-PDT is an effective method for the treatment of oral leukoplakia in elderly patients.
