Analysis of Massive Transfusion for Trauma Patients and Non-Trauma Patients in a Tertiary Hospital.
10.17945/kjbt.2016.27.3.237
- Author:
Hyerim KIM
1
;
Dong Won YOO
;
Kyung Hwa SHIN
;
Hyun Ji LEE
;
Hyung Hoi KIM
Author Information
1. Department of Laboratory Medicine, Pusan National University Hospital, Busan, Korea. hhkim@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Massive hemorrhage;
Massive transfusion;
Trauma;
Non-trauma;
Mortality
- MeSH:
Blood Transfusion;
Electronic Health Records;
Hemorrhage;
Humans;
Mortality;
Retrospective Studies;
Tertiary Care Centers*
- From:Korean Journal of Blood Transfusion
2016;27(3):237-246
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Management of patients with massive hemorrhage often requires the massive blood transfusions. However, few studies have investigated the effects of massive transfusions on non-traumatic patients. Therefore, this study analyzed mortality and descriptive data for patients receiving massive transfusion, including non-trauma patients and trauma patients. METHODS: We reviewed a retrospective audit of massive transfusions to investigate the major causes, patient characteristics, ratio of the blood components, and the mortality of massively transfused patients. The analysis was performed using electronic medical records collected from January 2010 to December 2013. Patients who had received a massive transfusion (≥10 units of RBCs within 24-hours) were categorized into trauma and non-trauma patients. We calculated the ratio of blood components and investigated the relationship between ratio and mortality. Descriptive statistics were used to characterize the patients and the indications. RESULTS: A total of 532 massive transfusions were performed, including 187 trauma and 345 non-trauma patients. The overall mortality rate was 32.0%, encompassing 36.4% of the trauma patients and 29.6% of the non-trauma patients. The mortality in trauma patients was significantly reduced (P<0.001) within the first 48-hours compared with that in non-trauma patients, which was due to the high FFP: RBC ratio transfusion. The annual FFP: RBC ratio in trauma patients showed an increasing trend. Non-trauma patients showed no relationship between mortality and procedure indication/blood component ratio. CONCLUSION: We report clinical data pertaining to massive transfusions. Annual increasing FFP: RBC ratio in trauma patients was associated with a decreasing mortality. Non-trauma patients showed heterogeneous characteristics and a lower FFP: RBC ratio than trauma patients.
